Fioricet is a medication that combats symptoms of migraines, cluster headaches. Tension headaches are also controlled with this medication. Acetaminophen aids in the reduction of headache pain. The effects of acetaminophen are enhanced by caffeine. A sedative called butalbital can make you feel relaxed, sleepy, and less anxious. The combination of acetaminophen, caffeine and butalbital produces a synergistic effect providing greater pain relief than that found with the single components.